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Tizanidine was approved for medical use in the United States in 1996. [5] It is available as a generic medication . [ 3 ] In 2022, it was the 94th most commonly prescribed medication in the United States, with more than 6 million prescriptions.
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Another class of antispasmodics for such treatment includes cyclobenzaprine, carisoprodol, diazepam, orphenadrine, and tizanidine. [7] Meprobamate is another effective antispasmodic which was first introduced for clinical usage in 1955 mainly as an anxiolytic and soon afterward became a blockbuster psychotropic drug.
Since many of the uses of antihistamines involve conditions such as rashes, which should be treatable by local application, there is some rationale for developing drugs for topical use.
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Here are links to possibly useful sources of information about Tizanidine. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .