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Structure of chlorhexidine, a bisbiguanide antiseptic.. Bisbiguanides are a class of chemically related compounds known for their bactericidal properties. Generally considered to be of the generic formula: R 1 R 2 N.C(:NR 6)NH.C(:NH)NH.CH 2 X--(CH 2) 3 NH.C(:NH)NH.C(:NR 7)NR 3 R 4 V. [1] These compounds include the antiseptics chlorhexidine and alexidine.
Chlorhexidine [1] is a disinfectant and antiseptic with the molecular formula C 22 H 30 Cl 2 N 10, which is used for skin disinfection before surgery and to disinfect surgical instruments. [2] It is also used for cleaning wounds , preventing dental plaque , treating yeast infections of the mouth , and to keep urinary catheters from blocking. [ 3 ]
Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, [ 4 ] it is spelled polihexanide ( INN ) and sold under various brand names. [ 5 ]
The biguanide polymer polyaminopropyl biguanide is specifically bactericidal at very low concentrations (10 mg/L). It has a unique method of action: The polymer strands are incorporated into the bacterial cell wall, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria.
ATC code D08 Antiseptics and disinfectants is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
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Alexidine is an antimicrobial of the biguanide class. [1] More specifically, it is a bisbiguanide. [2] References
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