Search results
Results from the WOW.Com Content Network
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.
Examples of Kunitz-type protease inhibitors are aprotinin (bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI). Kunitz STI protease inhibitor, the trypsin inhibitor initially studied by Moses Kunitz, was extracted from soybeans.
21789 Ensembl ENSG00000105825 ENSMUSG00000029664 UniProt P48307 O35536 RefSeq (mRNA) NM_006528 NM_001271003 NM_001271004 NM_009364 NM_001381907 NM_001381908 RefSeq (protein) NP_001257932 NP_001257933 NP_006519 NP_033390 NP_001368836 NP_001368837 Location (UCSC) Chr 7: 93.89 – 93.89 Mb Chr 6: 3.96 – 3.99 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tissue factor pathway ...
[1] [4] [2] It is a tissue factor pathway inhibitor (TFPI) antagonist. [4] It was developed by Pfizer. [5] Marstacimab is a new type of medication that, rather than replacing a clotting factor, works by reducing the amount, and therefore, the activity of, the naturally occurring anticoagulation protein called tissue factor pathway inhibitor. [4]
It is a serine protease inhibitor (serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
14723 Ensembl ENSG00000185245 ENSMUSG00000050675 UniProt P07359 O35930 RefSeq (mRNA) NM_000173 NM_010326 RefSeq (protein) NP_000164 NP_034456 Location (UCSC) Chr 17: 4.93 – 4.94 Mb Chr 11: 70.53 – 70.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Platelet glycoprotein Ib alpha chain, also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (C luster of D ...
Hexokinase ATP ADP Glucose 6-phosphate Glucose-6-phosphate isomerase Fructose 6-phosphate Phosphofructokinase-1 ATP ADP Fructose 1,6-bisphosphate Fructose-bisphosphate aldolase Dihydroxyacetone phosphate + + Glyceraldehyde 3-phosphate Triosephosphate isomerase 2 × Glyceraldehyde 3-phosphate 2 × Glyceraldehyde-3-phosphate dehydrogenase NAD + + P i NADH + H + NAD + + P i NADH + H + 2 × 1,3 ...
In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases (PPI) that catalyze the interconversion between the cis and trans isomers of peptide bonds containing the amino acid proline (Pro).