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The hepatocyte is a cell in the body that manufactures serum albumin, fibrinogen, and the prothrombin group of clotting factors (except for Factors 3 and 4). It is the main site for the synthesis of lipoproteins, ceruloplasmin, transferrin, complement, and glycoproteins. Hepatocytes manufacture their own structural proteins and intracellular ...
Cytology is the name given to the branch of biology that deals with the formation, structure and functionality of the cells. [1] Liver cytology specializes in the study of liver cells. The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages). [2]
These cells can differentiate into either hepatocytes or cholangiocytes. Cholangiocytes are the epithelial lining cells of the bile ducts. [80] They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.
Liver sinusoidal endothelial cell. Liver sinusoidal endothelial cells (LSECs) form the lining of the smallest blood vessels in the liver, also called the hepatic sinusoids. LSECs are highly specialized endothelial cells with characteristic morphology and function. They constitute an important part of the reticuloendothelial system (RES).
In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue, consisting of a portal triad, hepatocytes arranged in linear cords between a capillary network, and a central vein.
Hepatocytes are polyhedral in shape, therefore having no set shape or design, although they are made of cuboidal epithelial cells. They have surfaces facing the sinusoids (called sinusoidal faces) and surfaces which contact other hepatocytes (called lateral faces). Bile canaliculi are formed by grooves on some of the lateral faces of these ...
Cells derived from ectoderm. Toggle Cells derived from ectoderm subsection. Cells derived from mesoderm. Toggle Cells derived from mesoderm subsection. Paraxial mesoderm. Intermediate mesoderm. Lateral plate mesoderm. Cells derived from endoderm. Toggle Cells derived from endoderm subsection.
When hepatocytes or biliary cells are unable or blocked from regeneration, these cell types can function as facultative stem cells for each other. [5] [11] When hepatocytes cannot proliferate, biliary epithelial cells are capable of turning into hepatocytes. [5]