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In 2019, an estimated 6.5 million people worldwide had Chagas disease, with approximately 173,000 new infections and 9,490 deaths each year. [3] The disease resulted in a global annual economic burden estimated at US$7.2 billion in 2013, 86% of which is borne by endemic countries.
The coronavirus RNA genome has a 5′ methylated cap and a 3′ polyadenylated tail, which allows it to act like a messenger RNA and be directly translated by the host cell's ribosomes. The host ribosomes translate the initial overlapping open reading frames ORF1a and ORF1b of the virus genome into two large overlapping polyproteins, pp1a and ...
Instead of implementing a nationwide lockdown, the government applied "Large-Scale Social Restrictions" (Indonesian: Pembatasan Sosial Berskala Besar, abbreviated as PSBB), which was later modified into the "Community Activities Restrictions Enforcement" (Indonesian: Pemberlakuan Pembatasan Kegiatan Masyarakat, abbreviated as PPKM). [5]
A December 2020 systematic review and meta-analysis estimated that population IFR during the first wave of the pandemic was about 0.5% to 1% in many locations (including France, Netherlands, New Zealand, and Portugal), 1% to 2% in other locations (Australia, England, Lithuania, and Spain), and exceeded 2% in Italy. [357]