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The functions of the endoplasmic reticulum can be summarized as the synthesis and export of proteins and membrane lipids, but varies between ER and cell type and cell function. The quantity of both rough and smooth endoplasmic reticulum in a cell can slowly interchange from one type to the other, depending on the changing metabolic activities ...
The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. [3] The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. [ 4 ]
[3] [4] MCS are important in the function of the endoplasmic reticulum (ER), [5] since this is the major site of lipid synthesis within cells. [6] The ER makes close contact with many organelles, including mitochondria, Golgi, endosomes, lysosomes, peroxisomes, chloroplasts and the plasma membrane. [7]
Smooth endoplasmic reticulum makes hormones and lipids, degrades toxins, and controls cellular levels of calcium. Though most control of cell division is present in the nucleus, the centrosomes present in the endoplasm assist with spindle formation. The endoplasm is the site of many activities necessary for the cell to maintain homeostasis. [2]
Valosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase (TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. [5] [6] [7] The TER ATPase is an ATPase enzyme present in all eukaryotes and archaebacteria.
While the two membranes and the endoplasmic reticulum are linked, proteins embedded in the membranes tend to stay put rather than dispersing across the continuum. [18] It is lined with a fiber network called the nuclear lamina which is 10-40 nm thick and provides strength. [citation needed]
The endoplasmic reticulum (ER) is involved in conjugation of proteins to lipid and carbohydrate moieties synthesized by, or modified within, the hepatocytes. [citation needed] Proteins produced by hepatocytes that function as hormones are known as hepatokines. [citation needed]
SRP then targets this entire complex (the ribosome-nascent chain complex) to the protein-conducting channel, also known as the translocon, in the endoplasmic reticulum (ER) membrane. This occurs via the interaction and docking of SRP with its cognate SRP receptor [6] that is located in close proximity to the translocon.