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The whole procedure can be performed on cells from the blood, bone marrow or spinal fluid in a matter of a few hours. [citation needed] Immunophenotyping is a very common flow cytometry test in which fluorophore-conjugated antibodies are used as probes for staining target cells with high avidity and affinity.
Flow cytometry (FC) is a technique used to detect and measure the physical and chemical characteristics of a population of cells or particles. [1] [2] [3] [4]In this process, a sample containing cells or particles is suspended in a fluid and injected into the flow cytometer instrument.
Patients with this lymphoma commonly have an IgM gammaopathy, i.e. high blood levels of an IgM monoclonal protein. [ 6 ] Hairy cell leukemia: The monoclonal B-cells in this usually indolent CLL/SLL-like leukemia have a distinctive morphology and are CD5−, CD10−, CD19+, CD20+ (bright), CD23−, CD103+, CD200+, and complete Ig+.
The entire procedure, once preparation is complete, typically takes 10–15 minutes. If several samples are taken, the needle is removed between the samples to avoid blood coagulation. After the procedure is complete, the patient is typically asked to lie flat for 5–10 minutes to provide pressure over the procedure site.
Lymphoma is the most common form of hematological malignancy, or "blood cancer", in the developed world. Taken together, lymphomas represent 5.3% of all cancers (excluding simple basal cell and squamous cell skin cancers) in the United States and 55.6% of all blood cancers.
Lymphocytosis is usually detected when a complete blood count is obtained. If not provided the lymphocyte count can be calculated by multiplying the total white blood cell (WBC) count by the percentage of lymphocytes found in the differential count. [13] The lymphocyte count can also be directly measured by flow cytometry. [citation needed]
Further information about the specimen may be gained by immunohistochemical stains and molecular testing, particularly if the sample is prepared using liquid based cytology. Often "reflex" testing is performed, such as HPV testing on an abnormal pap test or flow cytometry on a lymphoma specimen.
[1] [2] Diagnoses and treatment of diseases such as leukemia and lymphoma often deal with hematopathology; techniques and technologies include flow cytometry studies [3] and immunohistochemistry. In the United States, hematopathology is a board-certified subspecialty by the American Board of Pathology. Board-eligible or board-certified ...
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