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Anti-transglutaminase antibodies (ATA) are autoantibodies against the transglutaminase protein. Detection is considered abnormal, and may indicate one of several conditions . Antibodies serve an important role in the immune system by detecting cells and substances that the rest of the immune system then eliminates.
Transglutaminase is also used in molecular gastronomy to meld new textures with existing tastes. Besides these mainstream uses, transglutaminase has been used to create some unusual foods. British chef Heston Blumenthal is credited with the introduction of transglutaminase into modern cooking.
Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family ...
Both anti-transglutaminase and anti-endomysial antibodies have high sensitivity to diagnose people with classic symptoms and complete villous atrophy, but they are only found in 30–89% of the cases with partial villous atrophy and in less than 50% of the people who have minor mucosal lesions (duodenal lymphocytosis) with normal villi. [23] [24]
Persons suspected of having celiac disease may undergo serological testing for IgA anti-tissue transglutaminase antibodies (abbreviated anti-tTG antibodies or anti-TG2 antibodies) and anti-endomysial antibodies (abbreviated EMA) provided the IgA-level is high, and if IgA is low, testing for certain IgG antibodies; in case of positive ...
Antibody recognition of gluten is complex. Direct binding to gluten such as anti-gliadin antibodies has an ambiguous pathogenesis in coeliac disease. The crosslinking of gliadin with tissue transglutaminase leads to the production of anti-transglutaminase antibodies, but this is mediated through T-cell recognition of gliadin.
Are Diabetes Weight Loss Drugs Safe? Generally speaking, GLP-1s, GIP/GLP-1s, and metformin are considered safe and effective when used as prescribed. That said, no medication is without side effects.
241636 Ensembl ENSG00000166948 ENSMUSG00000027403 UniProt O95932 n/a RefSeq (mRNA) NM_198994 NM_001254734 NM_001289747 NM_001289748 NM_001289749 NM_177726 RefSeq (protein) NP_001241663 NP_945345 n/a Location (UCSC) Chr 20: 2.38 – 2.43 Mb Chr 2: 129.95 – 130 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transglutaminase 6 is a protein that in humans is encoded by the TGM6 gene ...