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Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. [1] Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts of the body. [1] As clotting factors and platelets are used up, bleeding may occur. [1]
Acute fatty liver of pregnancy is a rare condition and occurs in approximately one in 7,000 to one in 15,000 pregnancies. [3] [19] The mortality from acute fatty liver of pregnancy has been reduced significantly to 18%, and is now related primarily to complications, particularly DIC (Disseminated Intravascular Coagulation) and infections.
It usually begins during the last three months of pregnancy or shortly after childbirth. [1] Symptoms may include feeling tired, retaining fluid, headache, nausea, upper right abdominal pain, blurry vision, nosebleeds, and seizures. [1] Complications may include disseminated intravascular coagulation, placental abruption, and kidney failure. [1]
This leads to the sequelae of DIC or Disseminated intravascular coagulation. [5] [7] It is also supposed that endothelin a potent vasoconstrictor is upregulated during the course of the amniotic fluid embolism in the maternal circulation. This endothelin acts in an antagonistic fashion to blood vessels causing intense vasoconstriction. [5]
Initial treatment for any type of transfusion reaction, including AHTR, is discontinuation of the transfusion. Fluid replacement and close monitoring of vital signs are important. People with AHTR are managed with supportive care , which may include diuretics , blood pressure support, and treatment of disseminated intravascular coagulation ...
[14] [5] Some possible predisposing factors to Sheehan's syndrome may include: disseminated blood coagulation (DIC), hypotension, small sella turcica size, and blood clots from a pre-existing hypercoagulable disorder. [9] Atony of the uterus is a leading cause of post-partum hemorrhage, therefore uterine atony could induce Sheehan's syndrome. [15]
Mother: disseminated intravascular coagulopathy, kidney failure [2] Baby: low birthweight, preterm delivery, stillbirth [2] Usual onset: 24 to 26 weeks of pregnancy [2] Causes: Unclear [2] Risk factors: Smoking, preeclampsia, prior abruption [2] Diagnostic method: Based on symptoms, ultrasound [1] Differential diagnosis: Placenta previa, bloody ...
The package insert states that prothrombin complex concentrate is contraindicated in patients with disseminated intravascular coagulation, a pathological activation of coagulation, [24] because giving clotting factors would only further fuel this process. However, if the PCC is given because factor levels are low, it can restore normal coagulation.