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Human karyogram. Neurogenetics studies the role of genetics in the development and function of the nervous system.It considers neural characteristics as phenotypes (i.e. manifestations, measurable or not, of the genetic make-up of an individual), and is mainly based on the observation that the nervous systems of individuals, even of those belonging to the same species, may not be identical.
The visual system is the physiological basis of visual perception (the ability to detect and process light).The system detects, transduces and interprets information concerning light within the visible range to construct an image and build a mental model of the surrounding environment.
Our goal was to map the genetic variants that influence brain structure and examine if these same genes also affect the risk of brain-related disorders,” noted Rentería. The results of the team ...
Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects adult males, and onset is more likely in younger adults.
The genes also play a role in the development and stability of the retina by influencing the structure and function of both the rod photoreceptor cells and supporting cells called the retinal pigmented epithelium. Mutations that affect the normal function of these genes can result in retinitis pigmentosa and resultant vision loss. [citation needed]
Fruitflies lacking the PAX6 gene have no eyes PAX6 is a member of the Pax gene family which is responsible for carrying the genetic information that will encode the Pax-6 protein. It acts as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures ...
Steady-state levels of endogenous DNA damages represent the balance between formation and repair. 8-OHdGs are among the most frequent DNA damages present in the steady-state, with about 2,400 8-OHdG damaged nucleotides in the average mammalian cell. [38] The steady state 8-OHdG level in the brain is similar to that in other tissues. [39]
The brain and eyes, for example, can be significantly impacted by mutations in this gene and cause disorders such as Microphthalmia and Holoprosencephaly. [39] Microphthalmia is a condition that affects the eyes, which results in small, underdeveloped tissues in one or both eyes. [39]