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The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. [2] [3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4]
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
When TNF binds to its receptors, tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2), a pathway of signals is triggered within the target cell, resulting in an inflammatory response. sTNF can only activate TNFR1, whereas tmTNF can activate both TNFR1 and TNFR2, [6] as well as trigger inflammatory signaling ...
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
27279 Ensembl ENSG00000006327 ENSMUSG00000023905 UniProt Q9NP84 Q9CR75 RefSeq (mRNA) NM_016639 NM_001161746 NM_013749 RefSeq (protein) NP_057723 NP_001155218 NP_038777 Location (UCSC) Chr 16: 3.02 – 3.02 Mb Chr 17: 23.89 – 23.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a ...
7133 21938 Ensembl ENSG00000028137 ENSMUSG00000028599 UniProt P20333 P25119 RefSeq (mRNA) NM_001066 NM_011610 RefSeq (protein) NP_001057 NP_035740 Location (UCSC) Chr 1: 12.17 – 12.21 Mb Chr 4: 144.94 – 144.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and ...
619441 Ensembl ENSG00000248871 ENSMUSG00000018752 UniProt O43508 n/a RefSeq (mRNA) NM_172089 NM_001034097 NM_001034098 NM_001159503 RefSeq (protein) NP_003800 n/a Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.57 – 69.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human ...
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/ TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.