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A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. [1] Contrast agents absorb or alter external electromagnetism or ultrasound , which is different from radiopharmaceuticals , which emit radiation themselves.
Contrast-enhanced ultrasound (CEUS) is the application of ultrasound contrast medium to traditional medical sonography. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. This may be the surface of a small air bubble or a more complex structure.
The Molecular Imaging and Contrast Agent Database or MICAD is a freely accessible online source of information on in vivo molecular imaging agents. It was established as a key component of the "Molecular Libraries and Imaging" program of the NIH Roadmap, a set of major inter-agency initiatives accelerating medical research and the development of new, more specific therapies for a wide range of ...
Contrast in ultrasound imaging relies on the difference in acoustic impedance, a function of both the speed of the ultrasound wave and the density of the tissues, [12] between tissues or regions of interest. [5] As the sound waves induced by ultrasound interact with a tissue interface, some of the waves are reflected back to the transducer.
A contrast medium for medical ultrasonography is a formulation of encapsulated gaseous microbubbles [64] to increase echogenicity of blood, discovered by Dr. Raymond Gramiak in 1968 [65] and named contrast-enhanced ultrasound. This contrast medical imaging modality is used throughout the world, [66] for echocardiography in particular in the ...
Lantheus Medical Imaging, GE Healthcare: Ultrasound Contrast Agents: Approved in the US and Europe [8] [28] [9] [29] C 4 F 10-1.9: Bubble: Perfluorobutane: Sonazoid: Daiichi Sankyo: Ultrasound Contrast Agent: Approved in Japan, [10] available in Korea, Norway, Taiwan, and China [30] C 5 F 12: 29: Bubble and/or Droplet: Dodecafluoropentane ...
uses ultrasound to produce images from within the body; video link: X-ray: uses X-rays to produce images of structures within the body; video link: Contrast media for X-rays: to provide a high contrast image of the details of the viscera under study; e.g. salts of heavy metals, gas like air, radio-opaque dyes, organic iodides, etc ...
Polymeric Gd 3+ chelates are large in size, which prevents leakage into the interstitial space, and provides long imaging windows. Several polymeric gadolinium-based BPAs are currently in development but have not yet been approved for clinical use: Gadomelitol (Guerbet, France), also known as Vistarem and P792 [19] Gadomer-17 (Schering AG, Berlin, Germany) also known as Gd-DTPA-17, SH L 643 A ...