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Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1]
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24] Chronic alcoholism is a contributing risk factor. Pantothenic acid (Vitamin B 5) deficiency: Irritability, fatigue, and ...
Pellagra (niacin or vitamin B 3 deficiency) [6] Gastroesophageal reflux disease, in such cases specifically called a water brash (a loosely defined lay term), and is characterized by a sour fluid or almost tasteless saliva in the mouth [7] Gastroparesis (main symptoms are nausea, vomiting, and reflux) Pregnancy; Fluoride therapy; Excessive ...
Kwashiorkor is a subtype of severe acute malnutrition (SAM) characterized by bilateral peripheral pitting edema. According to the World Health Organization, the SAM diagnosis parameters are a "mid-upper arm circumference (MUAC) of < 115 mm, weight-for-height/length Z-score (WHZ) of < -3Z and nutritional edema or any combination of these ...
Pellagra, a similar condition, is also caused by low nicotinamide; this disorder results in dermatitis, diarrhea, and dementia. [citation needed] Hartnup disease is a disorder of amino acid transport in the intestine and kidneys; otherwise, the intestine and kidneys function normally, and the effects of the disease occur mainly in the brain and ...
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In the 1930s, he contributed significantly to finding a cure for pellagra, a nutritional disease that once afflicted millions in the American South. Later, he also made a large contribution to finding cure for tropical sprue. For his efforts in elimination of pellagra, Time Magazine named him as 1938 "Man of the Year" in comprehensive science. [1]