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Old School RuneScape is a massively multiplayer online role-playing game (MMORPG), developed and published by Jagex.The game was released on 16 February 2013. When Old School RuneScape launched, it began as an August 2007 version of the game RuneScape, which was highly popular prior to the launch of RuneScape 3.
A beta version of RuneScape 2 was released to paying members for a testing period beginning on 1 December 2003, and ending in March 2004. [62] Upon its official release, RuneScape 2 was renamed simply RuneScape, while the older version of the game was kept online under the name RuneScape Classic.
A synapse during re-uptake. Note that some neurotransmitters are lost and not reabsorbed. Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
Long-term potentiation (LTP) is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse.Studies of LTP are often carried out in slices of the hippocampus, an important organ for learning and memory.
A dendritic spine (or spine) is a small membrane protrusion from a neuron's dendrite that typically receives input from a single axon at the synapse.Dendritic spines serve as a storage site for synaptic strength and help transmit electrical signals to the neuron's cell body.
The synapse is formed at a narrow gap between the pre- and postsynaptic neurons known as a gap junction. At gap junctions, such cells approach within about 3.8 nm of each other, [ 1 ] a much shorter distance than the 20- to 40-nanometer distance that separates cells at a chemical synapse . [ 2 ]
The neurotransmitters are released by the synapse to propagate the signal to the postsynaptic cell. It has also been hypothesized that synaptic fatigue could be a result of postsynaptic receptor desensitization or changes in postsynaptic passive conductance , but recent evidence has suggested that it is primarily a presynaptic phenomenon.
In a computational neural network, a vector or set of inputs and outputs , or pre- and post-synaptic neurons respectively, are interconnected with synaptic weights represented by the matrix , where for a linear neuron