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It is to be distinguished from two other primary cutaneous lymphomas that involve B-cells, primary cutaneous follicle center lymphoma (PCFCL) and primary cutaneous marginal zone lymphoma (PCMZL), [8] as well as from a B-cell lymphoma that at diagnosis may appear to be limited to the skin but often is a systemic disease affecting numerous organs ...
Primary cutaneous diffuse large B-cell lymphoma, leg type; Because recent studies had shown that primary cutaneous marginal zone lymphoma, which was formerly classified as a subtype of the MALT lymphomas: a) has a distinct microscopic histology and gene expression profile; b) spreads to extracutaneous tissue in only 4 to 8.5% of cases; c) has a ...
Cutaneous lymphoma, also known as lymphoma cutis, is when lymphoma involves the skin. [1] It is characterized by a proliferation of lymphoid tissue. [2] There are two main classes of lymphomas that affect the skin: [citation needed] Cutaneous T-cell lymphoma; Cutaneous B-cell lymphoma
Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, [1] is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time. Symptoms include rash, tumors, skin lesions, and itchy skin. While the cause remains unclear, most cases are not hereditary.
Spread from the skin is unusual, and the prognosis is excellent [2]: 218 with a 5-year survival of over 97%. [2]: 314 The International Extranodal Lymphoma Study Group identified elevated LDH, more than two skin lesions, and nodular lesions as three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (CLIPI), which is prognostic of disease-free status.
The "primary" used to designate cutaneous lymphomas indicates that the lymphoma was first diagnosed as limited to the skin and there was no evidence of spread to extracutaneous tissues for 6 months after the diagnosis was first made. [4]) In 2022, however, the International Consensus Classification (ICC) group of experts in various medical ...
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