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Chronic kidney disease–mineral and bone disorder (CKD–MBD) is one of the many complications associated with chronic kidney disease.It represents a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: [1] [2]
The homeostatic mechanism which controls the plasma sodium concentration is rather more complex than most of the other homeostatic mechanisms described on this page. The sensor is situated in the juxtaglomerular apparatus of kidneys, which senses the plasma sodium concentration in a surprisingly indirect manner.
Homeostatic capacity refers to the capability of systems to self-stabilize in response to external forces or stressors, or more simply the capability of systems to maintain homeostasis. [ 1 ] [ 2 ] For living organisms , it is life's foundational trait, consisting of a hierarchy and network of traits endowed by nature and shaped by natural ...
Bone resorption involves the breaking down of bone tissue and the transfer of calcium ions into the blood. [12] Bone resorption is carried out by specialized bone cells known as osteoclasts . [ 12 ] A surge in osteoclast activity can lead to hypercalciuria, as more bone tissue is broken down, meaning more calcium is released into the blood.
Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. [5] Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. [6] Osteocyte activity plays a key role in this process. Conditions ...
Homeostatic imbalances that can serve as internal stimuli include nutrient and ion levels in the blood, oxygen levels, and water levels. Deviations from the homeostatic ideal may generate a homeostatic emotion , such as pain, thirst or fatigue, that motivates behavior that will restore the body to stasis (such as withdrawal, drinking or resting).
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Osteoporosis, osteomalacia and rickets are bone disorders linked to calcium metabolism disorders and effects of vitamin D. Renal osteodystrophy is a consequence of chronic kidney failure related to the calcium metabolism. A diet adequately rich in calcium may reduce calcium loss from bone with advancing (post-menopausal) age. [11]