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Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
High dosage intravenous corticosteroids or plasmapheresis, designated for individuals not responding to steroids, make up the majority of acute management; Symptomatic management: Individuals with multiple sclerosis (MS) experience a range of symptoms, such as cognitive decline, discomfort, exhaustion, urinary problems, and stiffness.
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
When baclofen is administered intrathecally, it may cause CNS depression accompanied with cardiovascular collapse and respiratory failure. Tizanidine may lower blood pressure. This effect can be controlled by administering a low dose at the beginning and increasing it gradually. [42]
Intrathecal pumps require maintenance and need to be periodically refilled. How frequently this occurs is dependent on several factors, including drug concentration and dosage, and pump size. The refill frequency can range between one and six months for baclofen pumps. [2]
Baclofen [65] or tizanidine are sometimes used as an alternative to benzodiazepines. Tizanidine has been found to have superior tolerability compared to diazepam and baclofen. [66] Benzodiazepines are also used to treat the acute panic caused by hallucinogen intoxication. [67]
Intrathecal administration is often used for a single 24-hour dose of analgesia (opioid with local anesthetic). Caution should be exercised with intrathecal opioids due to the risk of late onset hypoventilation. The use of intrathecal morphine may be limited by severe pruritus and urinary retention. [citation needed]
In his paper, as in those that followed in JAMA, Lancet, CNS Drugs etc., Ameisen urged for randomised trials to test suppression of alcohol dependence using high-dose baclofen. [ 5 ] In 2008, Ameisen wrote a best-selling book, The End Of My Addiction , published in France as Le Dernier Verre ( The Last Glass ), describing his experience of ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261
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