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Testosterone undecanoate, or testosterone 17β-undecanoate, is a synthetic androstane steroid and a derivative of testosterone. [39] [40] It is an androgen ester; specifically, it is the C17β undecylate (undecanoate) ester of testosterone. [39] [40] A related testosterone ester with a similarly very long duration is testosterone buciclate. [9 ...
Since only the free testosterone is able to bind to tissue receptors to exert its effects, it is believed that free testosterone is the best marker of a person's androgen status. However, free testosterone is difficult and expensive to measure (it requires a time-consuming dialysis step), and many laboratories do not offer this service.
This is because testosterone levels in men are about 100 to 1,000 times higher than estradiol levels in women (300 to 1,000 ng/dL vs. 50 to 150 pg/mL, respectively). [50] Non-scrotal testosterone patches were assessed and were found to be ineffective in raising testosterone levels in men. [50]
Testosterone replacement therapies have been shown to improve blood glucose management. [13] [14] Still, "it is prudent not to start testosterone therapy in men with diabetes solely for the purpose of improving metabolic control if they show no signs and symptoms of hypogonadism." [15]
Dips in testosterone can cause low libido, brain fog, depression, and muscle loss, but it's pivotal you know your normal range, a doctor says.
The EC 50 of androstanolone for activation of the AR is 0.13 nM, which is about 5-fold stronger than that of testosterone (EC 50 = 0.66 nM). [43] In bioassays, androstanolone has been found to be 2.5- to 10-fold more potent than testosterone. [41] Upon intramuscular injection in rats, androstanolone is about 1.5- to 2.5-fold the potency of ...
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