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Lupron injection was approved by the FDA for treatment of advanced prostate cancer on 9 April 1985. [ 45 ] [ 4 ] [ 43 ] [ 44 ] Lupron depot for monthly intramuscular injection was approved by the FDA for palliative treatment of advanced prostate cancer on 26 January 1989.
A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
[28] [29] GnRH agonists commonly used are leuprorelin, goserelin, and triptorelin, which are marked as Lupron, Zoladex, and Decapetyl, respectively. [30] Nafarelin, marked as Synarel, is also occasionally prescribed in the form of nasal spray. [31] These drugs are all approved by the US FDA, and their working principles target both sexes equally.
Endo International creates histerelin acetate (Vantas) while AbbVie manufactures leuprolide acetate (Lupron Depot). [ 57 ] [ 58 ] Other companies within the United States are also in the mix such as Pfizer who distributes histerelin acetate (Supprelin LA) and Tolmar Pharmaceuticals who create their own leuprolide acetate (Fensolvi).
Later in the 1980s, the Lupron Depot technology further advanced the field by offering zero-order and long-term release systems. The intranasal route gained interest towards the end of the 20th century with treating cardiovascular and respiratory diseases.
In March 2011, Forum Invest co-organized, together with the Romanian Ministry of Foreign Affairs, the Romanian Ministry of Economy, the Federation of the Gulf Cooperation Council Chambers of Commerce and a number of other institutional partners, the first ever economic forum between Romania – South – Eastern Europe and the Gulf Cooperation Council, [3] aiming to boost economic cooperation ...
Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. [10] [4] It is used as a method of birth control and as a part of menopausal hormone therapy.
The Democratic Forum of Germans in Romania (German: Demokratisches Forum der Deutschen in Rumänien, DFDR; Romanian: Forumul Democrat al Germanilor din România, FDGR; in short Forumul German or Das Forum) is a political party (legally recognized as an association of public utility according to the governmental decision HG 599 as per 4 June 2008) organised on ethnic criteria representing the ...