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  2. Glycine - Wikipedia

    en.wikipedia.org/wiki/Glycine

    Glycine is thought to be a hepatic detoxifier of a number endogenous and xenobiotic organic acids. [44] Bile acids are normally conjugated to glycine in order to increase their solubility in water. [45] The human body rapidly clears sodium benzoate by combining it with glycine to form hippuric acid which is then excreted. [46]

  3. Glycine receptor - Wikipedia

    en.wikipedia.org/wiki/Glycine_receptor

    The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine. GlyR is an ionotropic receptor that produces its effects ...

  4. Glycinergic - Wikipedia

    en.wikipedia.org/wiki/Glycinergic

    A glycinergic agent (or drug) is a chemical which functions to directly modulate the glycine system in the body or brain. Examples include glycine receptor agonists , glycine receptor antagonists , and glycine reuptake inhibitors .

  5. Glycine cleavage system - Wikipedia

    en.wikipedia.org/wiki/Glycine_cleavage_system

    The glycine cleavage system (GCS) is also known as the glycine decarboxylase complex or GDC. The system is a series of enzymes that are triggered in response to high concentrations of the amino acid glycine. [1] The same set of enzymes is sometimes referred to as glycine synthase when it runs in the reverse direction to form glycine. [2]

  6. Drug action - Wikipedia

    en.wikipedia.org/wiki/Drug_action

    The action of drugs on the human body (or any other organism's body) is called pharmacodynamics, and the body's response to drugs is called pharmacokinetics. The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way.

  7. Glycine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Glycine_reuptake_inhibitor

    A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). ). Examples of GRIs include bitopertin (RG1678), iclepertin (BI-425809), ORG-24598, ORG-25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and ORG-25435 and N-arachidonylglycine, which are selective GlyT2 blo

  8. Neurotransmitter - Wikipedia

    en.wikipedia.org/wiki/Neurotransmitter

    Drugs targeting the neurotransmitter of major systems affect the whole system, which can explain the complexity of action of some drugs. Cocaine , for example, blocks the re-uptake of dopamine back into the presynaptic neuron, leaving the neurotransmitter molecules in the synaptic gap for an extended period of time.

  9. Strychnine - Wikipedia

    en.wikipedia.org/wiki/Strychnine

    Glycine acts primarily as an agonist of the glycine receptor, which is a ligand-gated chloride channel in neurons located in the spinal cord and in the brain. This chloride channel allows the negatively charged chloride ions into the neuron, causing a hyperpolarization which pushes the membrane potential further from threshold.

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