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Atrophic gastritis under low power. H&E stain. Autoimmune metaplastic atrophic gastritis (AMAG) is an inherited form of atrophic gastritis characterized by an immune response directed toward parietal cells and intrinsic factor. [6] Achlorhydria induces G cell (gastrin-producing) hyperplasia, which leads to hypergastrinemia.
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Stomach biopsy, to test for gastritis and other conditions [27] The OLGA staging frame of chronic gastritis on histopathology. Atrophy is scored as the percentage of atrophic glands and scored on a four-tiered scale. No atrophy (0%) = score 0; mild atrophy (1–30%) = score 1; moderate atrophy (31–60%) = score 2; severe atrophy (>60%) = score 3.
Diagram showing gastric pits (13) gastric glands (12) lamina propria (10) epithelium (11) Histology of normal fundic mucosa. Fundic glands are simple, branched tubular glands that extend from the bottom of the gastric pits to the muscularis mucosae; the more distinctive cells are parietal cells. H&E stain. Histology of normal antral mucosa.
Stomach diseases include gastritis, gastroparesis, Crohn's disease and various cancers. [1] The stomach is an important organ in the body. It plays a vital role in digestion of foods, releases various enzymes and also protects the lower intestine from harmful organisms. The stomach connects to the esophagus above and to the small intestine below.
Inflammation of the stomach by infection from any cause is called gastritis, and when including other parts of the gastrointestinal tract called gastroenteritis. When gastritis persists in a chronic state, it is associated with several diseases, including atrophic gastritis, pyloric stenosis, and gastric cancer.
Diagram of the alkaline mucous layer in the stomach with mucosal defense mechanisms. The gastric mucosa is the mucous membrane layer of the stomach, which contains the gastric pits, to which the gastric glands empty. In humans, it is about one mm thick, and its surface is smooth, soft, and velvety.
Gastritis The folds become very thick due to inflammation. [7] Peptic ulcer disease Ulcers cause breaks in the mucosa and cause erosion of the sub-mucosa. Zollinger-Ellison syndrome Gastrin levels increase due to tumors, which cause an increase in the gastric fold size. [7] Ménétrier's disease The mucosa pits are in excess causing thickening ...