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The 5-HT 3 receptor is expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions. [14] On a cellular level, it has been shown that postsynaptic 5-HT 3 receptors mediate fast excitatory synaptic transmission in rat neocortical interneurons, amygdala, and hippocampus, and in ferret visual ...
Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
The exception to this is the 5-HT 3 receptor which is a ligand-gated ion channel. In 2014, a novel 5-HT receptor was isolated from the small white butterfly, Pieris rapae, and named pr5-HT 8. It does not occur in mammals and shares relatively low similarity to the known 5-HT receptor classes. [7]
5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene. [5] [6] The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a ...
The 5-HT 3 receptor antagonists suppress vomiting and nausea by inhibiting serotonin binding to the 5-HT 3 receptors. The highest concentration of 5-HT 3 receptors in the central nervous system are found in the STN and chemoreceptor trigger zone (CTZ), and 5-HT 3 antagonists may also suppress vomiting and nausea by acting at these sites. [29]
The CTZ communicates with the other parts of the vomiting center through neurons that contain 5-HT 3, D 2, H 1 and H 2 receptors. [6] It has been seen that intraventricular administration of histamine in dogs causes an emetic response. [8] This shows that histamine plays a significant role in signaling for emetic action in the CTZ.
Approved 5-HT 3 inhibitors include dolasetron (Anzemet), granisetron (Kytril, Sancuso), and ondansetron (Zofran). Their antiemetic effect due to blockade of 5HT3 receptor on vagal afferent in the gut. in addition they also block 5-HT3 receptors in CTZ and STN. The newest 5-HT 3 inhibitor, palonosetron (Aloxi), also prevents delayed nausea and ...
n/a Ensembl ENSG00000178084 n/a UniProt Q8WXA8 n/a RefSeq (mRNA) NM_130770 n/a RefSeq (protein) NP_570126 n/a Location (UCSC) Chr 3: 184.05 – 184.06 Mb n/a PubMed search n/a Wikidata View/Edit Human 5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor. References ^ a b c GRCh38: Ensembl ...