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[12] [13] The Lewy body dementias—dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD)—are distinguished by the timing when cognitive and motor symptoms appear. [14] The two Lewy body dementias are often considered to belong on a spectrum of Lewy body disease that includes Parkinson's disease. [2] [5]
Parkinson's disease dementia (PDD) is dementia that is associated with Parkinson's disease (PD). [1] Together with dementia with Lewy bodies (DLB), it is one of the Lewy body dementias characterized by abnormal deposits of Lewy bodies in the brain. [2] [3] [4] [5]
Dementia with Lewy bodies and Parkinson's disease dementia are clinically similar after dementia occurs in Parkinson's disease. [151] Delusions in Parkinson's disease dementia are less common than in DLB, [152] and persons with Parkinson's disease are typically less caught up in their visual hallucinations than those with DLB. [85]
“In general, the etiology of dementia in Parkinson’s is thought to be a mix of Lewy body pathology primarily, but, also to varying extents, Alzheimer’s disease pathology and vascular disease ...
Parkinson-plus syndrome – Multiple diseases can be considered part of the Parkinson's plus group, including corticobasal syndrome, multiple system atrophy, progressive supranuclear palsy, and dementia with Lewy bodies. Differential diagnosis can be narrowed down with careful history and physical exam (especially focused on the sequential ...
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
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