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Chlorphentermine, sold under the brand names Apsedon, Desopimon, and Lucofen, is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the para-chloro derivative of the better-known appetite suppressant phentermine, which is still in current use.
Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
Mephentermine, sold under the brand name Wyamine among others, is a sympathomimetic medication which was previously used in the treatment of low blood pressure but is mostly no longer marketed. [ 6 ] [ 5 ] [ 4 ] [ 7 ] [ 8 ] It is used by injection into a vein or muscle , by inhalation , and by mouth .
When Grant Pierre lived in Texas, he saw a doctor with a similar business model as a patient and said after he turned 25 and was removed from his parents' health insurance, paying a monthly fee ...
In 2023, more than five million Americans 12 and older reported a "prescription use disorder" within the past year, according to the Centers for Disease Control and Prevention (CDC).
In 1959, phentermine had been FDA approved and fenfluramine in 1973. In the early 1990s two studies found that a combination of the drugs was more effective than either on its own; fen-phen became popular in the United States and had more than 18 million prescriptions in 1996. [ 40 ]
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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4]
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