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Lung parenchyma showing damage due to large subpleural bullae. Parenchyma (/ p ə ˈ r ɛ ŋ k ɪ m ə /) [1] [2] is the bulk of functional substance in an animal organ or structure such as a tumour. In zoology, it is the tissue that fills the interior of flatworms. In botany, it is some layers in the cross-section of the leaf. [3]
The human brain is the central organ of the nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sensory nervous system ...
The synapse is the primary unit of information transfer in the nervous system, and correct synaptic contact creation during development is essential for normal brain function. Genetic mutations can disrupt synapse formation and function, contributing to the development of neurodevelopmental and neurodegenerative disorders. [ 46 ]
[1] [2] The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system. [2] The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs.
The two layers of the dura mater separate at several places, with the meningeal layer projecting deeper into the brain parenchyma forming fibrous septa that compartmentalize the brain tissue. At these sites, the epidural space is wide enough to house the epidural venous sinuses. [2] [4] [5]
Viral encephalitis is inflammation of the brain parenchyma, called encephalitis, by a virus.The different forms of viral encephalitis are called viral encephalitides. It is the most common type of encephalitis and often occurs with viral meningitis.
Astrocytoma causes regional effects by compression, invasion, and destruction of brain parenchyma, arterial and venous hypoxia, competition for nutrients, release of metabolic end products (e.g., free radicals, altered electrolytes, neurotransmitters), and release and recruitment of cellular mediators (e.g., cytokines) that disrupt normal parenchymal function. [2]
The astrocytes of the glia limitans are responsible for separating the brain into two primary compartments. The first compartment is the immune-privileged brain and spinal cord parenchyma. This compartment contains multiple immunosuppressive cell surface proteins such as CD200 and CD95L and it allows for the release of anti-inflammatory factors.