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The axon hillock is the last site in the soma where membrane potentials propagated from synaptic inputs are summated before being transmitted to the axon. [2] For many years, it was believed that the axon hillock was the usual site of initiation of action potentials—the trigger zone.
At the axon hillock of a typical neuron, the resting potential is around –70 millivolts (mV) and the threshold potential is around –55 mV. Synaptic inputs to a neuron cause the membrane to depolarize or hyperpolarize ; that is, they cause the membrane potential to rise or fall.
Detail showing microtubules at axon hillock and initial segment. The axon hillock is the area formed from the cell body of the neuron as it extends to become the axon. It precedes the initial segment. The received action potentials that are summed in the neuron are transmitted to the axon hillock for the generation of an action potential from ...
The axon leaves the soma at a swelling called the axon hillock and travels for as far as 1 meter in humans or more in other species. It branches but usually maintains a constant diameter. At the farthest tip of the axon's branches are axon terminals, where the neuron can transmit a signal across the synapse to another cell. Neurons may lack ...
Therefore, the postsynaptic potential attenuates by the time it reaches the neuron cell body. The neuron cell body acts as a computer by integrating (adding or summing up) the incoming potentials. The net potential is then transmitted to the axon hillock, where the action potential is initiated. Another factor that should be considered is the ...
In addition, the axon hillock also has a specialized plasma membrane that contains large numbers of voltage-gated ion channels, since this is most often the site of action potential initiation and triggering. [5] The survival of some sensory neurons depends on axon terminals making contact with sources of survival factors that prevent apoptosis.
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Neural backpropagation is the phenomenon in which, after the action potential of a neuron creates a voltage spike down the axon (normal propagation), another impulse is generated from the soma and propagates towards the apical portions of the dendritic arbor or dendrites (from which much of the original input current originated).