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The two primary methods are testing for the female pregnancy hormone (human chorionic gonadotropin (hCG)) in blood or urine using a pregnancy test kit, and scanning with ultrasonography. [1] Testing blood for hCG results in the earliest detection of pregnancy. [ 2 ]
A later alternative to the rabbit test, known as the "Hogben test", used the African clawed frog, and yielded results without the need to cut the animal open. [6] Modern pregnancy tests continue to operate on the basis of testing for the presence of the hormone hCG in the blood or urine, but they no longer require the use of a live animal.
Around weeks 11–13, nuchal translucency scan (NT) may be offered which can be combined with blood tests for PAPP-A and beta-hCG, two serum markers that correlate with chromosomal abnormalities, in what is called the First Trimester Combined Test. The results of the blood test are then combined with the NT ultrasound measurements, maternal age ...
The triple test, also called triple screen, the Kettering test or the Bart's test, is an investigation performed during pregnancy in the second trimester to classify a patient as either high-risk or low-risk for chromosomal abnormalities (and neural tube defects). The term "multiple-marker screening test" is sometimes used instead.
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The test was developed by Leonard Apt (1922–2013), [3] an American pediatric ophthalmologist. The test was originally used to identify the source of bloody stools in newborn infants. It has been modified to distinguish fetal from maternal hemoglobin in blood samples from any source. [4]
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