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There is generally a reduction in the amount of air that the lungs can hold (vital capacity) and changes in expiratory function and lung elasticity. [80] [81] When the exposure to oxygen above 0.5 bar (50 kPa) is intermittent, it permits the lungs to recover and delays the onset of toxicity. [82]
Mucus is able to absorb water or dehydrate through pH variations. The swelling capacity of mucus stems from the bottlebrush structure [31] of mucin within which hydrophilic segments provide a large surface area for water absorption. Moreover, the tunability of swelling effect is controlled by polyelectrolyte effect.
Osmoregulation is the active regulation of the osmotic pressure of an organism's body fluids, detected by osmoreceptors, to maintain the homeostasis of the organism's water content; that is, it maintains the fluid balance and the concentration of electrolytes (salts in solution which in this case is represented by body fluid) to keep the body fluids from becoming too diluted or concentrated.
First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.
The oxygen affinity of the blood is related to lung volume. Where the lungs do not represent an oxygen store, the oxygen affinity is low to maximise the unloading of oxygen and to maintain a high tissue oxygen tension. Where the lungs are utilised as an oxygen store, the affinity is high and maximises uptake of oxygen from the alveolar volume. [13]
Control of the digestive system is also maintained by ENS, which can be thought of as a digestive brain that can help to regulate motility, secretion and growth. Sensory information from the digestive system can be received, integrated and acted upon by the enteric system alone. When this occurs, the reflex is called a short reflex. [4]
In some fish, capillary blood flows in the opposite direction to the water, causing countercurrent exchange. The muscles on the sides of the pharynx push the oxygen-depleted water out the gill openings. In bony fish, the pumping of oxygen-poor water is aided by a bone that surrounds the gills called the operculum. [6]
In PLV, the lungs are filled with the liquid, the patient is then ventilated with a conventional ventilator using a protective lung ventilation strategy. The hope is that the liquid will help the transport of oxygen to parts of the lung that are flooded and filled with debris, help remove this debris and open up more alveoli improving lung ...
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