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Hyaluronic acid injections, also known as knee gel injections, viscosupplementation, or rooster comb injections, can be an effective treatment for knee osteoarthritis.
In osteoarthritis, joint injection of glucocorticoids (such as hydrocortisone) leads to short term pain relief that may last between a few weeks and a few months. [5] Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis, [6] [7] but did increase risk of further pain. [6]
A 2020 meta-analysis found that intra-articular injection of high molecular weight HA improved both pain and function in people with knee osteoarthritis. [27] Hyaluronic acid has been used to treat dry eye. [28] Hyaluronic acid is a common ingredient in skin care products. Hyaluronic acid is used as a dermal filler in cosmetic surgery. [29]
It is injected into the joint capsule, to act as both a shock absorber and a lubricant for the joint. [ 3 ] [ 4 ] [ 5 ] Thus sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee , increasing the viscosity of the synovial fluid , which helps lubricate, cushion and reduce pain in the joint. [ 6 ]
Hyaluronic acid is a “great hydrator for pretty much all skin types,” one expert said.
A 2011 study reported histologically confirmed hyaline cartilage regrowth in the knee. The successful protocol involved arthroscopic microdrilling/ microfracture surgery followed by postoperative injections of autologous peripheral blood progenitor cells (PBPCs) and hyaluronic acid. [15]
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