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Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
In 1948, Rapport left the Cleveland Clinic for a position at Columbia University and continued searching for serotonin's structure. In May 1949, the structure of serotonin was discovered to be 5-hydroxytryptamine (5-HT). [3] Serotonin was found to be the same substance that Dr. Vittorio Erspamer had been studying since the 1930s called ...
Arda Alden Green (May 7, 1899 – January 22, 1958) was an American biochemist who co-discovered the neurotransmitter serotonin and discovered the reaction responsible for firefly bioluminescence. [1]
Subsequently, several non-tricyclic SSRIs were discovered and marketed. Fluoxetine, which was FDA approved in 1987, is usually thought to be the first SSRI to be marketed. The work which eventually led to the discovery of fluoxetine began at Eli Lilly and Company in 1970 as a collaboration between Bryan Molloy and Ray Fuller. [10]
In 1948, Maurice M. Rapport, Arda Green, and Irvine Page of the Cleveland Clinic discovered a vasoconstrictor substance in blood serum, and since it was a serum agent affecting vascular tone, they named it serotonin. [6] [7] In 1952 it was shown that enteramine was the same substance as serotonin. [8]
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
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For example, the precursor of serotonin is the amino acid tryptophan. ... a 20 to 40 nm gap between neurons, known today as the synaptic cleft, was discovered.