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CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The TCR complex and CD4 bind to distinct regions of the antigen-presenting MHC class II molecule. The extracellular D 1 domain of CD4 binds to the β2 region of MHC class II.
Binding generally refers to a mapping of one thing to another. In the context of software libraries, bindings are wrapper libraries that bridge two programming languages, so that a library written for one language can be used in another language. [1] Many software libraries are written in system programming languages such as C or C++.
Dynamic binding (or late binding or virtual binding) is name binding performed as the program is running. [2] An example of a static binding is a direct C function call: the function referenced by the identifier cannot change at runtime. An example of dynamic binding is dynamic dispatch, as in a C++ virtual method call.
CPython is the reference implementation of the Python programming language. Written in C and Python, CPython is the default and most widely used implementation of the Python language. CPython can be defined as both an interpreter and a compiler as it compiles Python code into bytecode before interpreting it.
The CD receptor family typically act as co-receptors, illustrated by the classic example of CD4 acting as a co-receptor to the T cell receptor (TCR) to bind major histocompatibility complex II (MHC-II). [5] This binding is particularly well-studied in T-cells where it serves to activate T-cells that are in their resting (or dormant) phase and ...
CD4 immunoadhesin was first developed in the mid-1990s as a potential therapeutic agent and treatment for HIV/AIDS. The protein is a fusion of the extracellular domain of the CD4 receptor and the Fc domain of human immunoglobulin G (IgG), the most abundant antibody isotype in the human body. [1]
GObject Introspection is a middleware layer between C libraries (using GObject) and language bindings, e.g. PyGObject uses this, while PyGTK does not. [ 2 ] Official GNOME Bindings follow the GNOME release schedule which guarantees API stability and time-based releases.
In a June 2008 issue of the journal Autoimmunity Review, [10] [11] researchers S. Planque, Sudhir Paul, Ph.D., and Yasuhiro Nishiyama, Ph.D. of the University Of Texas Medical School at Houston announced that they have engineered an abzyme that degrades the superantigenic region of the gp120 CD4 binding site.