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  2. Intravitreal injection - Wikipedia

    en.wikipedia.org/wiki/Intravitreal_injection

    Intravitreal injection is the method of administration of drugs into the eye by injection with a fine needle. The medication will be directly applied into the vitreous humor. [1] It is used to treat various eye diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and infections inside the eye such as endophthalmitis. [1]

  3. Intravitreal administration - Wikipedia

    en.wikipedia.org/wiki/Intravitreal_administration

    In 2005 bevacizumab and ranibizumab intravitreal injections for the treatment of wet-AMD caused a rise in injections to 252,000. [2] In 2008, over 1 million intravitreal injections were performed. This doubled to 2 million just 3 years later in 2011 when another anti-VEGF intravitreal injection aflibercept became available for the treatment of ...

  4. Aflibercept - Wikipedia

    en.wikipedia.org/wiki/Aflibercept

    A 2017 review update studying the effects of anti-VEGF drugs on diabetic macular edema found that while all three studied treatments have advantages over laser therapy, there was moderate evidence that aflibercept is significantly favored in all measured efficacy outcomes over ranibizumab and bevacizumab, after one year, longer term advantages ...

  5. Diabetic retinopathy - Wikipedia

    en.wikipedia.org/wiki/Diabetic_retinopathy

    Diabetic retinopathy (also known as diabetic eye disease) is a medical condition in which damage occurs to the retina due to diabetes.It is a leading cause of blindness in developed countries and one of the lead causes of sight loss in the world, even though there are many new therapies and improved treatments for helping people live with diabetes.

  6. Anti-VEGF - Wikipedia

    en.wikipedia.org/wiki/Anti-VEGF

    By May 2012, anti-VEGF treatment with Avastin has been accepted by Medicare, is quite reasonably priced, and effective. Lucentis has a similar but smaller molecular structure to Avastin, and is FDA-approved (2006) for treating MacD, yet remains more costly, as is the more recent (approved in 2011) aflibercept (Eylea). Tests on these treatments ...

  7. Ixoberogene soroparvovec - Wikipedia

    en.wikipedia.org/wiki/Ixoberogene_soroparvovec

    Ixoberogene soroparvovec (Ixo-vec, also known as ADVM-022), is a gene therapy developed by Adverum Biotechnologies for wet age-related macular degeneration. It is delivered via the viral vector AAV.7m8. [1] [2]

  8. Vascular endothelial growth factor - Wikipedia

    en.wikipedia.org/wiki/Vascular_endothelial...

    Between 1996 and 1997, Christinger and De Vos obtained the crystal structure of VEGF, first at 2.5 Å resolution and later at 1.9 Å. [7] [8] [9] Fms-like tyrosine kinase-1 (flt-1) was shown to be a VEGF receptor by Ferrara et al. in 1992. [10] The kinase insert domain receptor (KDR) was shown to be a VEGF receptor by Terman et al. in 1992 as ...

  9. Rubeosis iridis - Wikipedia

    en.wikipedia.org/wiki/Rubeosis_iridis

    If caught early, the neovascularization can be reversed with prompt panretinal photocoagulation (PRP), or injection of anti-VEGF medications with subsequent PRP. The injection blocks the direct effect of VEGF and acts more quickly but will wear off in about six weeks. [4] PRP has a slower onset of action but can last permanently.

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