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  2. Intravitreal injection - Wikipedia

    en.wikipedia.org/wiki/Intravitreal_injection

    Intravitreal injection is the method of administration of drugs into the eye by injection with a fine needle. The medication will be directly applied into the vitreous humor. [1] It is used to treat various eye diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and infections inside the eye such as endophthalmitis. [1]

  3. Intravitreal administration - Wikipedia

    en.wikipedia.org/wiki/Intravitreal_administration

    In 2005 bevacizumab and ranibizumab intravitreal injections for the treatment of wet-AMD caused a rise in injections to 252,000. [2] In 2008, over 1 million intravitreal injections were performed. This doubled to 2 million just 3 years later in 2011 when another anti-VEGF intravitreal injection aflibercept became available for the treatment of ...

  4. Diabetic retinopathy - Wikipedia

    en.wikipedia.org/wiki/Diabetic_retinopathy

    Diabetic retinopathy (also known as diabetic eye disease) is a medical condition in which damage occurs to the retina due to diabetes.It is a leading cause of blindness in developed countries and one of the lead causes of sight loss in the world, even though there are many new therapies and improved treatments for helping people live with diabetes.

  5. Ixoberogene soroparvovec - Wikipedia

    en.wikipedia.org/wiki/Ixoberogene_soroparvovec

    Ixoberogene soroparvovec (Ixo-vec, also known as ADVM-022), is a gene therapy developed by Adverum Biotechnologies for wet age-related macular degeneration. It is delivered via the viral vector AAV.7m8. [1] [2]

  6. Aflibercept - Wikipedia

    en.wikipedia.org/wiki/Aflibercept

    A 2017 review update studying the effects of anti-VEGF drugs on diabetic macular edema found that while all three studied treatments have advantages over laser therapy, there was moderate evidence that aflibercept is significantly favored in all measured efficacy outcomes over ranibizumab and bevacizumab, after one year, longer term advantages ...

  7. Macular degeneration - Wikipedia

    en.wikipedia.org/wiki/Macular_degeneration

    These anti-VEGF agents may be administered monthly or adaptively. For adaptive anti-VEGF treatment, two approaches are conventionally applied. In the case of pro re nata , the patient comes at fixed intervals, but treatment is only administered if an activity is detected (i.e., presence of fluid).

  8. VEGFR-2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/VEGFR-2_inhibitor

    VEGFR-2 is a 210-230 kDa glycoprotein expressed in vascular endothelial cells and in hematopoietic stem cells and binds VEGF-A. [2] [4] VEGFR-2 is closely related to VEGFR-1 for they have common and specific ligands but VEGFR-2 is a highly active kinase while VEGFR1 is an impaired receptor tyrosine kinase.

  9. Rubeosis iridis - Wikipedia

    en.wikipedia.org/wiki/Rubeosis_iridis

    The injection blocks the direct effect of VEGF and acts more quickly but will wear off in about six weeks. [4] PRP has a slower onset of action but can last permanently. Once the neovascularization has been longstanding, the new vessels recruit fibrous tissue, and as this forms and contracts, the angle can be permanently damaged, and will not ...

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