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A midlife crisis is a transition of identity and self-confidence that can occur in middle-aged individuals, typically 45 to 64/65 years old. [1] [2] [3] The phenomenon is described as a psychological crisis brought about by events that highlight a person's growing age, inevitable mortality, and possible lack of accomplishments in life.
A stressor is a chemical or biological agent, environmental condition, external stimulus or an event seen as causing stress to an organism. [1] Psychologically speaking, a stressor can be events or environments that individuals might consider demanding, challenging, and/or threatening individual safety.
Schematic overview of the classes of stresses in plants Neurohormonal response to stress. Stress, whether physiological, biological or psychological, is an organism's response to a stressor such as an environmental condition. [1] When stressed by stimuli that alter an organism's environment, multiple systems respond across the body. [2]
Midlife crises of the past were once usually defined by lavish purchases—whether on expensive cars, extended vacations, cross-country or cross-world moves, or costly cosmetic surgery.
These changes can lead to transgenerational stress inheritance. [1] Epigenetic modifications play a role in the development and heritability of these disorders and related symptoms. For example, regulation of the hypothalamus-pituitary-adrenal axis by glucocorticoids plays a major role in stress response and is known to be epigenetically regulated.
Prolonged stress can disturb the immune, digestive, cardiovascular, sleep, and reproductive systems. [17] For example, it was found that: Chronic stress reduces resistance of infection and inflammation, and might even cause the immune system to attack itself. [27] Stress responses can cause atrophy of muscles and increases in blood pressure. [28]
A typical allostatic response has been initiated by a stressor and then continues for the duration of the stressor, in which it shuts off as the stressor has ended. Allostatic load is the accumulation of stressors and maladaptive responses that may result in an extreme state, where the stress response does not terminate. [26]
Once the stressor is resolved, the body resumes to amounting an adequate immune and inflammatory response, which may explain why it is often seen that a person falls ill after acute stress. Due to the interconnected nature of the brain's regulation of stress, the immune system, and the endocrine system, allostasis may play a role in the ...