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Centralized web application that provides data format transformations and facilitates connections with other bioinformatics tools Web browser: LGPL: Broad Institute, collaborative project GENtle: An equivalent to the proprietary Vector NTI, a tool to analyze and edit DNA sequence files Linux, macOS, Windows: GPL: Magnus Manske: gget
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It has since been adopted for use as a tool in the genetic engineering of higher organisms. Designing an appropriate gRNA is an important element of genome editing with the CRISPR/Cas system. A gRNA can and at times does have unintended interactions ("off-targets") with other locations of the genome of interest.
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GIMP: Free image editor and graphics creator Spencer Kimball, Peter Mattis: January 1996: 2.10.38 [9] 2024-05-05 Free GPL-3.0-or-later: GimPhoto: Modification of the free and open-source graphics program GNU Image Manipulation Program (GIMP), with the intent to be a free alternative to Adobe Photoshop. Ek Kian 24.1 December 30, 2014: Free GPL-2 ...
Cytidine base editor is a novel therapy in which the cytidine (C) changes to thymidine (T). Adenine base editor (ABE), [214] in this there is a change in base complements from adenine (A) to Guanine (G). The mutations were directly installed in cellular DNA so that the donor template is not required. The base editings can only edit point mutations.
These tools use different mechanisms to bind a predetermined sequence of DNA (“target”), which they cleave (or "cut"), creating a double-stranded chromosomal break (DSB) that summons the cell's DNA repair mechanisms (non-homologous end joining and homologous recombination ) and leads to site-specific modifications. [2]
Access to the code governing the DNA recognition by transcription activator-like effectors (TALE) in 2009 opened the way to the development of a new class of efficient TAL-based gene editing tools. TALE, proteins secreted by the Xanthomonas plant pathogen, bind with great specificity to genes within the plant host and initiate transcription of ...