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Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). [ 2 ] [ 8 ] Early on, there are typically no symptoms. [ 2 ] Later, non-painful lymph node swelling, feeling tired, fever , night sweats , or weight loss for no clear reason may occur.
The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. [5] TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. [12]
In the EU, venetoclax monotherapy is indicated for the treatment of chronic lymphocytic leukemia (CLL) in the presence of 17p deletion or TP53 mutation in adults who are unsuitable for or have failed a B cell receptor pathway inhibitor and for the treatment of CLL in the absence of 17p deletion or TP53 mutation in adults who have failed both ...
CLL/SLL is the most common adult leukemia in Western countries, accounting for 1.2% of the new cancers diagnosed each year in the United States. It usually occurs in older adults (median age at diagnosis 70) and follows an indolent course over many years. [11] About 1-10% of CLL/SLLs develop a Richter's transformation at a rate of 0.5–1% per ...
TP53 mutations have also been expressed in cells that exhibit shorter [clarification needed] and are more end-end fusion prone. It is also hypothesized that TP53 mutations may be implicated in premature chromosome condensation. TP53 may also contribute to the ability of cells to survive the catastrophic event that normally would be considered ...
Virtual karyotype of a chronic lymphocytic leukemia sample using a SNP array. ... 9/13 had homozygous TP53 mutations underlying the 17p UPD. In addition, in cases ...
Mutations to this gene have also been documented in other hematologic malignancies. [17] TP53 is an important transcriptional activator of genes involved in the regulation of the G1 checkpoint of the cell cycle as well as certain genes responsible for programmed-cell death . It is believed that mutations to TP53 are responsible for the frequent ...
Chromosome abnormalities, single nucleotide polymorphisms (SNPs, i.e. substitutions of a single nucleotide in a DNA sequence at a specific position in the genome) and gene mutations, while each occurs in <15% of cases, [12] are present in CLL/SLL MBL and to some extent are similar to those found in CLL/SLL. For example, position 21.33 to 22.2 ...