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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Baclofen, diazepam and dantrolene remain the three most commonly used pharmacologic agents in the treatment of spastic hypertonia. Baclofen is generally the drug of choice for spinal cord types of spasticity, while sodium dantrolene is the only agent which acts directly on muscle tissue. Tizanidine is also available.
Patient education is a planned interactive learning process designed to support and enable expert patients [1] to manage their life with a disease and/or optimise their health and well-being. [ 2 ] [ 3 ]
In 2008, Ameisen wrote a best-selling book, The End Of My Addiction, published in France as Le Dernier Verre (The Last Glass), describing his experience of curing his alcoholism with baclofen. [6] In 2007, an Italian team also showed the effectiveness and the safety of baclofen as a treatment for alcohol addiction. [7]
A baclofen pump has been used to treat patients of all ages exhibiting muscle spasticity along with dystonia. The pump delivers baclofen via a catheter to the thecal space surrounding the spinal cord. The pump itself is placed in the abdomen. It can be refilled periodically by access through the skin. Baclofen can also be taken in tablet form [40]
Baclofen (β-(4-chlorophenyl)-GABA) – antispasmodic drug; potent GABA B receptor agonist, weak inhibitor of α 2 δ subunit-containing VGCCs; Tolibut (β-(4-methylphenyl)-GABA) – analgesic, tranquilizing, and neuroprotective drug; Phaclofen (phosphonobaclofen) – GABA B receptor antagonist; Saclofen (sulfonobaclofen) – GABA B receptor ...
Probably, only some benign patients with opioid resistant pain or serious side effects are suitable for intrathecal treatment. [clarification needed] Baclofen pumps are often used for individuals with spasticity associated with quadriplegia or paraplegia [1]
Patient Education and Counseling is a monthly peer-reviewed medical journal covering patient education and health communication, especially counseling. It was established in 1979 as Patient Counselling and Health Education , obtaining its current name in 1983.