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2. Acetonitrile - Wikipedia

   en.wikipedia.org/wiki/Acetonitrile

   Acetonitrile is used mainly as a solvent in the purification of butadiene in refineries. Specifically, acetonitrile is fed into the top of a distillation column filled with hydrocarbons including butadiene, and as the acetonitrile falls down through the column, it absorbs the butadiene which is then sent from the bottom of the tower to a second separating tower.

3. High-performance liquid chromatography - Wikipedia

   en.wikipedia.org/wiki/High-performance_liquid...

   HPLC has many applications in both laboratory and clinical science. It is a common technique used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity. [59] While HPLC can produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk drug materials. [60]

4. Liquid chromatography–mass spectrometry - Wikipedia

   en.wikipedia.org/wiki/Liquid_chromatography...

   In common applications, the mobile phase is a mixture of water and other polar solvents (e.g., methanol, isopropanol, and acetonitrile), and the stationary matrix is prepared by attaching long-chain alkyl groups (e.g., n-octadecyl or C 18) to the external and internal surfaces of irregularly or spherically shaped 5 μm diameter porous silica ...

5. Acetonitrile (data page) - Wikipedia

   en.wikipedia.org/wiki/Acetonitrile_(data_page)

   Vapor-liquid Equilibrium for Acetonitrile/Methanol [4] P = 760 mmHg BP Temp. °C % by mole methanol liquid vapor 79.20: 2.5: 9.5 77.95: 4.0: 13.5 76.77: 5.5: 17.5 75. ...

6. Two-dimensional chromatography - Wikipedia

   en.wikipedia.org/wiki/Two-dimensional_chromatography

   The sample is first subjected to analysis by HPLC and then is subjected to mass analysis. Different types of mass analyzers, ToF, qudrupole, etc., can be used in the MS. [5] Common solvents used in normal or reversed phase LC such as water, acetonitrile, and methanol are all compatible with ESI, yet a LC grade solvent may not be suitable for MS.

7. Aqueous normal-phase chromatography - Wikipedia

   en.wikipedia.org/wiki/Aqueous_normal-phase...

   Mobile phases for ANPC are based on organic solvents as bulk solvents (such as methanol or acetonitrile) with a small amount of water as a modifier of polarity; thus, the mobile phase is both "aqueous" (water is present) and "normal phase type" (less polar than the stationary phase).

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9. Reversed-phase chromatography - Wikipedia

   en.wikipedia.org/wiki/Reversed-phase_chromatography

   This is a crucial property for common reversed phase chromatography since sample components are typically detected by UV detectors. Acetonitrile is more transparent than the others in low UV wavelengths range, therefore it is used almost exclusively when separating molecules with weak or no chromophores (UV-VIS absorbing groups), such as ...