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The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
Vascular dementia; The misfolding of proteins is a common component of the proposed pathophysiology of many aging-related diseases. However, there is insufficient evidence to prove this. For example, the tau hypothesis for Alzheimer's proposes that tau protein accumulation results in the breakdown of neuron cytoskeletons, leading to Alzheimer's ...
A normal brain on the left and a late-stage Alzheimer's brain on the right. During the final stage, known as the late-stage or severe stage, there is complete dependence on caregivers. [19] [33] [41] Language is reduced to simple phrases or even single words, eventually leading to complete loss of speech.
Familial Alzheimer's disease mutations commonly used in animal models. Rodent animal models of Alzheimer's disease are commonly used in research as rodents and humans have many of the same major brain regions and neurotransmitter systems. [5] These models are small, easy to house, as well as breed very well. [26]
This is an accepted version of this page This is the latest accepted revision, reviewed on 24 January 2025. Long-term brain disorders causing impaired memory, thinking and behavior This article is about the cognitive disorder. For other uses, see Dementia (disambiguation). "Senile" and "Demented" redirect here. For other uses, see Senile (disambiguation) and Demented (disambiguation). Medical ...
Three people died from bleeding while taking Leqembi in studies done before the drug was approved, says a Georgetown pharmacology professor.
One study took advantage of biomarkers, namely one called neurofilament light chain (NFL), in patients with Alzheimer's disease. Neurofilament light chain is a protein that is important in the growth and branching of neurons—cells found in the brain. In Alzheimer's Disease, neurons will stop working or die in a process called ...
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