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Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances which undergo alpha decay to treat diseased tissue at close proximity. [1] It has the potential to provide highly targeted treatment, especially to microscopic tumour cells.
The decay properties of actinium-225 are favorable for usage in targeted alpha therapy (TAT); clinical trials have demonstrated the applicability of radiopharmaceuticals containing 225 Ac to treat various types of cancer. However, the scarcity of this isotope resulting from its necessary synthesis in cyclotrons limits its potential applications.
[5] [6] Radium-223 dichloride is an alpha particle-emitting radiotherapy drug that mimics calcium and forms complexes with hydroxyapatite at areas of increased bone turnover. [7] The principal use of radium-223, as a radiopharmaceutical to treat metastatic cancers in bone , takes advantage of its chemical similarity to calcium , and the short ...
This is a type of targeted therapy which uses the physical, chemical and biological properties of the radiopharmaceutical to target areas of the body for radiation treatment. [3] The related diagnostic modality of nuclear medicine employs the same principles but uses different types or quantities of radiopharmaceuticals in order to image or ...
Alpha radiation is a nuclear phenomenon in which a heavy radionuclide emits an energetic alpha particle (consisting of two protons and two neutrons) and transmutes to a different radionuclide. The emitted alpha particle has a range in tissue of only 40-90 microns, which minimizes collateral damage when used for treatment purposes.
Some examples of alpha-emitting radioligands include actinium-225, Ra-223-chloride, and Lead-212.36 Schematic illustrating the differences in path length and intensity of alpha, beta, gamma, and x-rays. β particles emit lower energy as compared to α-emitters, but they have the advantage of having longer path length.
The Drug Enforcement Administration will visit doctors who go over the patient cap. State Medicaid officials may try to reject the patients or refuse to reimburse doctors over problems with paperwork. Local counseling services may be unwilling to provide therapy to their patients. Other doctors may see these physicians as on the fringes of ...
Particle therapy is a form of external beam radiotherapy using beams of energetic neutrons, protons, or other heavier positive ions for cancer treatment. The most common type of particle therapy as of August 2021 is proton therapy. [1]