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Tubulovillous adenoma (tubular component – left of image, villous component – right of image). H&E stain. The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion of the colorectal adenocarcinoma (colon cancer). [1][2][3] They often manifest as colorectal polyps.
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). [5] Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, abdominal pain and fatigue. [9] Most colorectal cancers are due to lifestyle ...
The vast majority of colorectal cancers are adenocarcinomas. [1] The histopathology of colorectal cancer of the adenocarcinoma type involves analysis of tissue taken from a biopsy or surgery. A pathology report contains a description of the microscopical characteristics of the tumor tissue, including both tumor cells and how the tumor invades ...
Total mesorectal excision. Total mesorectal excision (TME) is a standard surgical technique for treatment of rectal cancer, first described in 1982 by Professor Bill Heald at the UK's Basingstoke District Hospital. [1][2] It is a precise dissection of the mesorectal envelope comprising rectum containing the tumour together with all the ...
Lower anterior resection. A lower anterior resection, formally known as anterior resection of the rectum and colon and anterior excision of the rectum or simply anterior resection (less precise), is a common surgery for rectal cancer and occasionally is performed to remove a diseased or ruptured portion of the intestine in cases of diverticulitis.
William Ernest Miles (1869–1947), an English surgeon first performed the surgery of removing the rectum in 1907. He assumed that the rectal cancer can spread in both upwards and downward directions, thus necessitating the removal of the entire rectum together with the anal sphincters, resulting in a permanent stoma by connecting the proximal end of the descending colon to the skin.
Many seborrheic keratoses on back of person with Leser–Trélat sign due to colon cancer. Examples of cancers where adenocarcinomas are a common form: esophageal cancer; most cases in the developed world are adenocarcinomas. [2] pancreas; over 80% of pancreatic cancers are ductal adenocarcinomas. [3] prostate cancer is nearly always adenocarcinoma
Colon cancer staging. Colon cancer staging is an estimate of the amount of penetration of a particular cancer. It is performed for diagnostic and research purposes, and to determine the best method of treatment. The systems for staging colorectal cancers depend on the extent of local invasion, the degree of lymph node involvement and whether ...
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