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The DNA attaches to the flow cell via complementary sequences. The strand bends over and attaches to a second oligo forming a bridge. A polymerase synthesizes the reverse strand. The two strands release and straighten. Each forms a new bridge (bridge amplification). The result is a cluster of DNA forward and reverse strand clones.
The flow cell is exposed to reagents for polymerase-based extension, and priming occurs as the free/distal end of a ligated fragment "bridges" to a complementary oligo on the surface. Repeated denaturation and extension results in localized amplification of DNA fragments in millions of separate locations across the flow cell surface. Solid ...
A bridge-parallel amplifier topology is a hierarchical combination of the bridged and paralleled amplifier topologies, with at least four single-ended channels needed to produce one bridge-parallel channel. The two topologies complement each other in that the bridging allows for higher voltage output and the paralleling provides the current ...
Reduces the 6dB attenuation incurred by impedance matching, which helps by reducing the amount of make-up amplification required [5] and by maintaining a high signal-to-noise ratio. [6] [4] However a transformer can be used instead to match impedance and provide better signal-to-noise. And the 6dB attenuation can be easily be made up in the ...
However, other earlier patented technologies, such as that from Manteia Predictive Medicine (acquired by Solexa), which generate DNA on a solid-phase surface by bridge amplification, are generally referred to as "clusters". The terminology and distinction between 'polony' and 'cluster' have become confused recently.
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Sensor inputs can be accelerometer, thermocouple, thermistor, resistance thermometer, strain gauge or bridge, and LVDT or RVDT. Specialized inputs include encoder, counter or tachometer, timer or clock, relay or switch, and other specialized inputs. Outputs for signal conditioning equipment can be voltage, current, frequency, timer or counter ...