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Primary ovarian insufficiency (POI), also called premature ovarian insufficiency and premature ovarian failure, is the partial or total loss of reproductive and hormonal function of the ovaries before age 40 because of follicular (egg producing area) dysfunction or early loss of eggs.
Recent studies have validated the use of serum AMH levels as a marker for the quantitative aspect of ovarian reserve. Because of the lack of cycle variations in serum levels of AMH, this marker has been proposed to be used as part of the standard diagnostic procedures to assess ovarian dysfunctions, such as premature ovarian failure.
Fragile X-associated primary ovarian insufficiency (FXPOI) is the most common genetic cause of premature ovarian failure in women with a normal karyotype 46,XX. [1] The expansion of a CGG repeat in the 5' untranslated region of the FMR1 gene from the normal range of 5-45 repeats to the premutation range of 55-199 CGGs leads to risk of FXPOI for ovary-bearing individuals. [2]
Primary ovarian insufficiency (POI), which used to be called premature ovarian failure, is when the ovaries don’t make the typical amounts of estrogen or release eggs regularly before the age of ...
Smoking has also been found to increase follicular atresia and lead to premature ovarian failure. [27] Some of the short term effects of POF are hot flashes, irregular heart beat/heart palpitations , night sweats, urogenital symptoms, and headaches; some of the more long-term consequences of POF are osteoporosis , infertility, cardiovascular ...
Premature ovarian failure (before 40) Early onset menopause (before 45) Having severe vasomotor symptoms (such as hot flashes) in menopause.
In 2015 a research was done on the role of autoimmunity in premature ovarian failure. [11] In 2014 there was an ovarian autoimmune disease research that revealed at least two mechanisms that protect the ovary from an autoimmune attack. [12] Research showed that Theca cells were targeting the autoimmune deficiency within the ovary.
Premature ovarian insufficiency (POI) is impairment of the ovaries and how they work before the age of 40 years. It can be caused by multiple factors, one being genetic. Genes and their influence determine the initial number of the primordial follicles, impact on the rate of follicular atresia , and are impactful on the age of menopause .