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Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. [5] [6] [7]Keratin 20 is a type I cytokeratin.It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa.
The term cytokeratin began to be used in the late 1970s, when the protein subunits of keratin intermediate filaments inside cells were first being identified and characterized. [2] In 2006 a new systematic nomenclature for mammalian keratins was created, and the proteins previously called cytokeratins are simply called keratins (human ...
Cytokeratin 20: Extramammary Paget's disease of endodermal origin Merkel cell carcinoma: Colloidal iron: Papular mucinosis Scleredema Pretibial myxedema: Congo red: Amyloidosis Colloid milium: Crystal violet: Amyloidosis Colloid milium: D2-40: Lymphangioma circumscriptum: de Galantha: Pseudogout: Dylon: Amyloidosis: Epithelial membrane antigen ...
Cytokeratin-negative CTCs are characterised by the lack of EpCAM or cytokeratins, which may indicate an undifferentiated phenotype (circulating cancer stem cells) or the acquisition of a mesenchymal phenotype (known as epithelial-mesenchymal transition or EMT). These populations of CTCs may be the most resistant and most prone to metastasis.
Type I keratins (or Type I cytokeratins) are cytokeratins that constitute the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells.
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The antibody cocktail binds to cytokeratin 1 - 8, 10, 14 - 16 and 19 (but not CK17 or CK18). [1] It is therefore used as a marker of carcinomas, such as depth of invasion and metastases. [ 1 ] For example, it is both relatively sensitive and specific for detection of breast cancer metastasis to sentinel lymph nodes .
Today's Wordle Answer for #1270 on Tuesday, December 10, 2024. Today's Wordle answer on Tuesday, December 10, 2024, is PATIO. How'd you do? Next: Catch up on other Wordle answers from this week.