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Chromium(III) nicotinate is an ionic substance used for chromium supplementation in some nutritional products, where it is also referred to as chromium polynicotinate. It appears in products that are referred to as a medical food used for nutritional support for conditions associated with diabetes mellitus type 2 .
Chromium(III) picolinate (also trivalent chromium) is a chemical compound with the formula Cr(C 5 H 4 N(CO 2)) 3, commonly abbreviated as CrPic 3. It is a bright-red coordination compound derived from chromium (III) and picolinic acid .
In 2005, the U.S. Food and Drug Administration approved a Qualified Health Claim for chromium picolinate with a requirement for very specific label wording: "One small study suggests that chromium picolinate may reduce the risk of insulin resistance, and therefore possibly may reduce the risk of type 2 diabetes.
Trivalent chromium, or chromium(III), is an essential trace mineral in the human diet. [3] In some nutritional supplements, chromium(III) occurs as chromium(III) picolinate (in which chromium is bound to picolinic acid) or chromium(III) nicotinate (in which chromium is bound to nicotinic acid). Nicotinic acid is also known as the B vitamin niacin.
Picolinic acid is an organic compound with the formula NC 5 H 4 CO 2 H.It is a derivative of pyridine with a carboxylic acid (COOH) substituent at the 2-position. It is an isomer of nicotinic acid and isonicotinic acid, which have the carboxyl side chain at the 3- and 4-positions, respectively.
Recent studies have raised concerns about the potential health risks associated with certain nicotine salt formulations. For example, research published in *Toxics* in January 2024 highlighted that lactic acid salts of nicotine could significantly increase the transfer of toxic metals, such as nickel and chromium, into e-cigarette aerosols.
In 2005, the U.S. Food and Drug Administration had approved a qualified health claim for chromium picolinate with a requirement for specific label wording: "One small study suggests that chromium picolinate may reduce the risk of insulin resistance, and therefore possibly may reduce the risk of type 2 diabetes.
Chromium(III) picolinate Index of chemical compounds with the same molecular formula This set index page lists chemical structure articles associated with the same molecular formula .