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Metreleptin, sold under the brand name Myalept among others, is a synthetic analog of the hormone leptin used to treat various forms of dyslipidemia.It has been approved in Japan for metabolic disorders including lipodystrophy and in the United States as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired ...
Acquired generalized lipodystrophy (AGL), also known as Lawrence syndrome[ 1 ] and Lawrence–Seip syndrome, [ 1 ] is a rare skin condition that appears during childhood or adolescence, characterized by fat loss affecting large areas of the body, particularly the face, arms, and legs. [ 2 ]: 496 There are four types of lipodystrophy based on ...
Lipodystrophy. Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue. [1][2] The medical condition is characterized by abnormal or degenerative conditions of the body's adipose tissue. A more specific term, lipoatrophy (from Greek lipo 'fat' and dystrophy ...
Sub-Group Analysis Shows Investigational Metreleptin Treatment Demonstrated Reductions in HbA1c, Triglycerides and Liver Function Tests in Pediatric Patients with Lipodystrophy During a 12-Month ...
U.S. FDA Grants Priority Review to Bristol-Myers Squibb and AstraZeneca's Metreleptin, an Investigational Agent for Treatment of Metabolic Disorders Associated with Rare Forms of Lipodystrophy ...
Congenital generalized lipodystrophy (also known as Berardinelli–Seip lipodystrophy) is an extremely rare autosomal recessive condition, characterized by an extreme scarcity of fat in the subcutaneous tissues. [ 2 ] It is a type of lipodystrophy disorder where the magnitude of fat loss determines the severity of metabolic complications. [ 3 ]
Leptin. Not to be confused with Lectin, Lecithin, or Lepton. Leptin (from Greek λεπτός leptos, "thin" or "light" or "small"), also known as obese protein, [ 6 ] is a protein hormone predominantly made by adipocytes (cells of adipose tissue). Its primary role is likely to regulate long-term energy balance. [ 7 ]
Familial partial lipodystrophy, also known as Köbberling–Dunnigan syndrome, [ 2 ] is a rare genetic metabolic condition characterized by the loss of subcutaneous fat. [ 3 ]: 495. FPL also refers to a rare metabolic condition in which there is a loss of subcutaneous fat in the arms, legs and lower torso. The upper section of the body, face ...