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Other causes of peptic ulcer disease include gastric ischaemia, drugs, metabolic disturbances, cytomegalovirus (CMV), upper abdominal radiotherapy, Crohn's disease, and vasculitis. [15] Gastrinomas (Zollinger–Ellison syndrome), or rare gastrin-secreting tumors, also cause multiple and difficult-to-heal ulcers. [34]
Causes of gastric outlet obstruction include both benign causes, such as peptic ulcer disease affecting the area around the pylorus, and malignant causes, such as gastric cancer. Causation related to ulcers may involve severe pain which the patient may interpret as a heart condition or attack.
The ulcer is known initially as a peptic ulcer before the ulcer burns through the full thickness of the stomach or duodenal wall. A diagnosis is made by taking an erect abdominal/chest X-ray (seeking air under the diaphragm). This is in fact one of the very few occasions in modern times where surgery is undertaken to treat an ulcer. [3]
DeCoste explains that there are two primary causes of stomach ulcers. One is due to high dose or continued use of non-steroidal anti-inflammatory medications , such as ibuprofen, naproxen or aspirin.
Extension of the ulcer through the lining of the digestive tract results in spillage of the stomach or intestinal contents into the abdominal cavity, leading to an acute chemical peritonitis. [13] [14] Helicobacter pylori infection and overuse of non-steroidal anti-inflammatory drugs [15] [16] may contribute to formation of peptic ulcers.
Whereas ordinary peptic ulcers are found commonly in the gastric antrum and the duodenum, stress ulcers are usually found in the fundic mucosa and can be located anywhere within the stomach and proximal duodenum. Stress ulcers tend to present with multiple lesions whereas in peptic ulcers this is much more uncommon.
Peptic ulcers are sores or defects that arise from tissue death, that develop in the mucosal lining of the stomach or duodenum. [7] When a peptic ulcer bursts, the gastrointestinal or duodenal fluid leaks through it and pools in the right paracolic gutter [ 2 ] which leads to inflammation of the peritoneum resulting in symptoms right lower ...
Prolonged bleeding may cause anemia leading to weakness and fatigue. Inflammation of the pyloric antrum, which connects the stomach to the duodenum, is more likely to lead to duodenal ulcers, while inflammation of the corpus may lead to a gastric ulcer. Stomach cancer can cause nausea, vomiting, diarrhoea, constipation, and unexplained weight ...
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