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Effects generally begin within three hours and last for up to three days. [2] Long-term treatment with chlortalidone is more effective than hydrochlorothiazide for prevention of heart attack or stroke. [5] Common adverse effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction.
Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit; in the ALLHAT study, a chlorthalidone dose of 12.5 mg was used, with titration up to 25 mg for those subjects who did not achieve blood pressure control at 12.5 mg. Chlorthalidone has repeatedly been found to have a stronger ...
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Hydrochlorothiazide appears be more effective than chlorthalidone in preventing heart attacks and strokes. [14] Hydrochlorothiazide is less potent but may be more effective than chlorthalidone in reducing blood pressure. [14] [15] More robust studies are required to confirm which drug is superior in reducing cardiovascular events. [16]
Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure. [2] [3] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic. [4] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually. [5] It is taken by ...
Chlorthalidone < 50 Indapamide < 5 ... Long term administration of thiazide diuretics reduces total body blood volume. ... This page was last edited on 21 October ...
Grade 1 hypertension. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial, also known as ALLHAT, was a randomized, double-blind, active-controlled study comparing at the same time, four different classes of antihypertensive drugs with the rate of coronary heart disease (CHD) events in ‘high-risk’ people with hypertension. [1]
A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does not have the chemical properties of a thiazide, lacking the benzothiadiazine molecular structure. Examples include metolazone, chlorthalidone, and indapamide. [1]
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