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The AMPA receptor bound to a glutamate antagonist showing the amino terminal, ligand binding, and transmembrane domain, PDB 3KG2. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate and predominantly Na + ion channel that mediates fast synaptic transmission in the ...
AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na + and K + and therefore have an equilibrium potential near 0 mV. AMPA was first synthesized, along with several other ibotenic acid derivatives, by Krogsgaard-Larsen, Honoré, and others toward differentiating glutamate sensitive receptors from ...
α-Methylphenylalanine (α-MePhe or AMPA) is an artificial amino acid and a phenethylamine and amphetamine derivative. [1] It is the α- methylated analogue of phenylalanine , the precursor of the catecholamine neurotransmitters , and the amino acid analogue of amphetamine (α-methylphenethylamine), a psychostimulant and monoamine releasing agent .
CX-516, one of the earliest and a prototypical AMPAR PAM.It is a low-impact AMPAR PAM. Tulrampator (S-47445, CX-1632), a newer and high-impact AMPAR PAM.. AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the AMPA receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system.
Ampakines or AMPAkines are a subgroup of AMPA receptor positive allosteric modulators with a benzamide or closely related chemical structure. [ 1 ] [ 2 ] They are also known as "CX compounds". [ 1 ] Ampakines take their name from the AMPA receptor (AMPAR), a type of ionotropic glutamate receptor with which the ampakines interact and act as ...
The name "NMDA receptor" is derived from the ligand N-methyl-D-aspartate (NMDA), which acts as a selective agonist at these receptors. When the NMDA receptor is activated by the binding of two co-agonists, the cation channel opens, allowing Na + and Ca 2+ to flow into the cell, in turn raising the cell's electric potential. Thus, the NMDA ...
Pages in category "AMPA receptor agonists" The following 6 pages are in this category, out of 6 total. This list may not reflect recent changes. A. AMPA; D. Domoic ...
Receptors can be activated by either endogenous agonists (such as hormones and neurotransmitters) or exogenous agonists (such as drugs), resulting in a biological response.A physiological agonist is a substance that creates the same bodily responses but does not bind to the same receptor.