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In eukaryote cells, RNA polymerase III (also called Pol III) is a protein that transcribes DNA to synthesize 5S ribosomal RNA, tRNA, and other small RNAs. The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions.
RNA polymerase I synthesizes a pre-rRNA 45S (35S in yeast), which matures and will form the major RNA sections of the ribosome. RNA polymerase II synthesizes precursors of mRNAs and most sRNA and microRNAs. RNA polymerase III synthesizes tRNAs, rRNA 5S and other small RNAs found in the nucleus and cytosol.
74414 Ensembl ENSG00000186141 ENSMUSG00000028099 UniProt Q9BUI4 Q9D483 RefSeq (mRNA) NM_001303456 NM_006468 NM_028925 RefSeq (protein) NP_001290385 NP_006459 NP_083201 Location (UCSC) Chr 1: 145.82 – 145.84 Mb Chr 3: 96.62 – 96.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene ...
The perinucleolar compartment relies on RNA binding proteins and RNA polymerase III transcripts to stabilize its structure. Therefore, the continuous production of these transcripts is pivotal. During permeabilization of cells, RNase, but not DNase, destroys the PNC establishing the importance of RNA to the structure. [1]
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [11] It consists of RNA polymerase II, a subset of general transcription factors , and regulatory proteins known as SRB proteins.
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB).
DNA polymerase III synthesizes base pairs at a rate of around 1000 nucleotides per second. [3] DNA Pol III activity begins after strand separation at the origin of replication. Because DNA synthesis cannot start de novo, an RNA primer, complementary to part of the single-stranded DNA, is synthesized by primase (an RNA polymerase): [citation ...
Robert G. Roeder (born June 3, 1942, in Boonville, Indiana, United States) is an American biochemist.He is known as a pioneer scientist in eukaryotic transcription.He discovered three distinct nuclear RNA polymerases in 1969 [1] and characterized many proteins involved in the regulation of transcription, including basic transcription factors and the first mammalian gene-specific activator over ...